LEARNING FROM FAILURE - RATIONALE AND DESIGN FOR A STUDY ABOUT DISCONTINUATION OF RANDOMIZED TRIALS (DISCO STUDY)

Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

Abstract Background Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futility.Other RCTs are discontinued early because of insufficient recruitment.Trial discontinuation has ethical implications, because participants consent on the premise of contributing to new medical knowledge, Research Ethics Committ

read more

Evaluation of the efficacy of bleach routinely used in health facilities against mycobacterium tuberculosis isolates in Ethiopia

INTRODUCTION: in Ethiopia, the most widely used disinfectant is 5% Hypochlorites.However, Ethiopian national health safety and infection prevention guideline recommendation on the use of bleach is not consistent and varying from 0.1%-4%.The purpose of this study was therefore to assess the effective time-concentration relationship of sodium hypochl

read more


A two-decade Review of Medical Ethics in Iran

"nThe growing developments in science and technology have raised ethical challenges which should practically be addressed by scientists, regulatory bodies and policy makers.Likewise, challenging issues of medical ethics have also drawn a great deal of academic attention in Iran.In other words, recent decades have been an occasion of considerab

read more